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The Science of Longevity: What You Need to Know To Live Longer!

Do you want to live a long and healthy life? Of course, you do! In this blog post, we will discuss the science of longevity and what you need to know to live a longer and healthier life.

We will cover everything from diet and exercise to free radicals and inflammation. So whether you are looking to live a few more years or decades, read on for helpful tips that will help you achieve optimal health!

The Life Expectancy in the US

Life expectancy in the United States has been steadily rising for decades. In 1860, the average lifespan was just over 40 years. Today, it is closer to 79 years. This increase is due to many factors, including advances in medical care, improvements in sanitation and nutrition, and more.

One of the most important factors in longevity is access to quality healthcare. In the early days of the United States, medical care was rudimentary at best. There were no antibiotics or vaccines, and many diseases went untreated. As medical care has improved, so has a life expectancy.

Today, we have a better understanding of how to prevent and treat disease. We have vaccines that can prevent deadly illnesses and antibiotics that can treat infections. We also have a better understanding of nutrition and how it affects our health. All of these factors have contributed to the increase in life expectancy in the United States.

However, despite these advances, life expectancy in the United States has actually decreased in recent years. In 2015, life expectancy dropped for the first time since 1993. This is due to a number of factors, including unbalanced diets and sedentary lifestyles, high medical costs, and increasing rates of suicide and drug use.

As we age, our bodies go through a lot of changes. Sometimes it is helpful to understand things deeply. When we know what is happening in the body, we are more likely to do something about it.

Here are some factors that affect our aging process at the molecular level.

Advanced Glycation End Products: AGES

We all know that too much sugar is bad for our health. But did you know that there’s something called Advanced Glycation End Products, or AGES? AGES are formed when sugar molecules bind to proteins or fats. These sticky substances change the proteins’ shape and structure so that they don’t work well in the body. This process can cause inflammation, which is linked to many chronic diseases.

Moreover, AGES can cause wrinkles. When they bind to collagen and elastin, two proteins that give skin its youthful appearance, they make it more rigid. This process is called glycation, and it’s one of the main reasons why our skin ages.

So how can we avoid AGES? Well, we can’t totally avoid them since they’re present in many foods. AGES are found in foods that have been cooked at high temperatures, such as grilled meat. They’re also found in processed foods that contain lots of sugar, such as cookies and cake.

The best way to avoid AGES is to eat a healthy diet. Eat plenty of fruits, vegetables, and whole grains. And limit your intake of sugary foods and processed foods. Exercise can also help since it helps the body get rid of sugar molecules before they have a chance to bind to proteins. By making these simple changes, we can help keep our bodies and skin looking young and healthy.

Free Radicals And Antioxidants

When it comes to longevity, free radicals are one of the biggest enemies. These unstable molecules damage cells, leading to inflammation and a host of other problems. But what exactly are free radicals, and how do they affect our health?

Free radicals are molecules with unpaired electrons. These unstable molecules are produced naturally in the body as a byproduct of metabolism. However, they can also be created by environmental factors like pollution and UV exposure. Once created, free radicals start a chain reaction that damages cells, proteins, and DNA.

This damage leads to inflammation, which is a major contributing factor to many age-related diseases. In fact, studies have shown that free radical damage is a major cause of cellular aging. So if you want to live a long and healthy life, it’s important to protect yourself from free radicals.

While you can’t completely avoid free radicals, there are many things you can do to protect yourself from their damage. One way to protect yourself from free radicals is to eat a healthy diet that includes plenty of antioxidants.

Antioxidants neutralize free radicals, preventing them from causing damage. Foods that are high in antioxidants include fruits, vegetables, and whole grains. You can also get antioxidants from supplements, but it’s best to get them from food first.

Another way to protect yourself from free radicals is to avoid environmental factors that can cause them. This includes things like pollution and UV exposure. You can also limit your exposure to free radicals by not smoking and avoiding excessive alcohol consumption.

Mitochondrial dysfunction

Mitochondrial dysfunction is a major contributing factor to aging and age-related diseases. When mitochondria are not functioning properly, they produce harmful byproducts that can damage cells and lead to inflammation. This can cause a variety of age-related diseases, such as Alzheimer’s disease, Parkinson’s disease, cancer, and heart disease.

There are a few things that can affect the mitochondria and lead to mitochondrial dysfunction. One is oxidative stress, which occurs when there is an imbalance between the production of reactive oxygen species and the body’s ability to detoxify them. This can damage DNA and other cellular components, leading to inflammation.

Another factor is elevated glucose in the blood. Elevated glucose stops the mitochondria from intaking the fatty acids needed to produce energy, and this impairs mitochondrial function. This can lead to the formation of advanced glycation end products, which can damage proteins and DNA. 

So, what can you do to prevent or reverse mitochondrial dysfunction? One thing is to eat a healthy diet that includes plenty of antioxidants. This can help reduce oxidative stress and protect cells from damage. Another is to exercise regularly, which can help improve mitochondrial function and increase the production of new mitochondria. Finally, you can take supplements that contain nutrients that are essential for mitochondrial health,  such as CoQ-10 and alpha-lipoic acid.


Inflammation is a natural process that helps the body heal. However, when inflammation becomes chronic, it can contribute to many age-related diseases, including Alzheimer’s disease, arthritis, and cancer. Chronic inflammation can also make the aging process itself accelerate.

There are many things you can do to reduce chronic inflammation and its effects on aging. Eating a healthy diet is one of the best ways to reduce inflammation. Foods that are high in antioxidants, omega-three fatty acids, and phytochemicals can help to fight inflammation.

Exercise is also beneficial for reducing inflammation. Regular physical activity helps to reduce levels of inflammation-promoting chemicals in the body.

Managing stress is another important way to reduce chronic inflammation. Stress can increase inflammation, so it’s important to find ways to manage stress effectively. Meditation, yoga, and deep breathing are all excellent ways to manage stress.

Finally, getting enough sleep is crucial for reducing inflammation. Sleep helps to regulate the body’s inflammatory response.

By following these simple tips, you can help to reduce chronic inflammation and its effects on aging. By taking care of yourself, you can age more gracefully and stay healthy for years to come.

Endothelial dysfunction

Endothelial dysfunction is a major factor in the development of cardiovascular disease and plays an important role in the aging process. The endothelium is a layer of cells that line the blood vessels and helps to regulate blood flow. When this layer becomes damaged, it can lead to a number of health problems, including high blood pressure, heart disease, and stroke.

Endothelial dysfunction is often caused by a buildup of plaque in the arteries, which can restrict blood flow and lead to inflammation. This can be exacerbated by other factors such as smoking, diabetes, and high cholesterol.

Fortunately, there are a number of things that you can do to help prevent or reduce endothelial dysfunction.

Exercise is one of the best ways to improve endothelial function. Physical activity helps to increase blood flow and reduce inflammation. Eating a healthy diet is also important. Foods that are high in antioxidants, such as fruits and vegetables, can help to protect the endothelium from damage. Additionally, avoiding smoking and managing chronic conditions such as diabetes and high cholesterol can also help to reduce the risk of developing endothelial dysfunction.


There are many factors that affect our aging process. Advanced Glycation End Products (AGEs) and free radicals contribute to the formation of wrinkles and other signs of aging. Mitochondrial dysfunction and inflammation can lead to the development of age-related diseases. Endothelial dysfunction contributes to the hardening of arteries and the development of cardiovascular disease.

Although we cannot change all of the factors that affect our aging process, we can take steps to minimize their impact. We can eat a healthy diet, exercise regularly, and avoid smoking. These lifestyle choices will help us to age gracefully and live long healthy lives.

If you’re looking for more tips and help on how to age gracefully, contact our team of experts today! We can help you develop a personalized plan to keep you looking and feeling your best.

Hi! I’m Dr. E, The NP with a PHD. Several years ago, my wife was diagnosed with an autoimmune disease and the only options given to us were heavy duty medications.

We KNEW there had to be a better way. After a long search, we discovered functional medicine.

With functional medicine we found alternative ways we were able to manage her disease and get her back to feeling like her old self.

We discovered that this way of life not only helps people with various issues, including autoimmune, chronic issues and “I-don’t-feel-good-itis.”

Functional medicine drastically changed our lives and using it I developed The KNEW Method to help others who are suffering or not feeling optimal.

Let’s work together to get you to feeling like your old self again.

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